The Y-Box Binding Protein 1 Suppresses Alzheimer’s Disease Progression in Two Animal Models
Fig 10
YB-1 prevents formation of de novo β-amyloid fibrils and contributes to disruption of already formed fibril nets.
A, mature fibrils formed by the Aβ(1–42) peptide after 24 h incubation at 37°C in 10 mM imidazole, pH 7.0, 30 mM KCl; B, YB-1 after 24 h incubation in the same conditions; C, 24 h co-incubation of the Aβ(1–42) peptide and YB-1 in the same conditions; D, mature Aβ(1–42) fibrils were supplemented with YB-1 and incubated for 24 h in the same conditions.