Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases
Fig 6
Structures of MKP102, MKP103, MKP104, and MKP105.
MKP102 and 103 are derivatives that possess a methyl group at the C-3 and C-2 positions of the indole ring, respectively. MKP104 is a derivative with a methyl group on the indole nitrogen. MKP105 is a regioisomer of MKP101.