Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis
Fig 1
Schematic signalling pathways after formation of AngII and Ang-(1–7).
In the RAS angiotensinogen is cleaved by renin to AngI. AngI is cleaved on the one side to AngII, a major vasoconstrictor and ligand of the AT1R. In the following JAK2 activates RhoA. Subsequently, the myosin light chain phosphatase (MLCP) is inhibited, which promotes cell contraction. On the other side, AngII can be cleaved by ACE2 to Ang-(1–7), the ligand of the MasR. The MasR mediates vasodilatation via NO and PKG, which activates the MLCP leading to relaxation. The marker for PKG is VASP-phosphorylation.