A Novel Bmal1 Mutant Mouse Reveals Essential Roles of the C-Terminal Domain on Circadian Rhythms
Fig 6
The effects of C-terminal region of Bmal1 on the molecular circadian rhythm.
(A) The structures of BMAL1wt and Bmal1 mutant constructs, Bmal1GTΔC, Bmal1ΔC and Bmal1 ΔN. (B) The representative circadian oscillation profiles of the contructs in (A). The constructs were trasfected to WT MEFs. The luciferase activities of Bmal1 and Per2 promoters were distinguished by the wavelength separation method (n = 3).