Tumor Necrosis Factor - Alpha Is Essential for Angiotensin II-Induced Ventricular Remodeling: Role for Oxidative Stress
Fig 7
Effect of TNF-α inhibition with etanercept on Ang II-induced AT1R gene expression, NF-κB activity, and phosphorylation of p38 MAPK and JNK in WT mice.
(a) AT1R gene expression was significantly elevated in heart tissue by Ang II infusion, which was attenuated by etanercept treatment. (b) Chronic Ang II infusion significantly increased cardiac NF-κB p65 activity in WT mice but not in mice treated with etanercept. (c) p38 MAPK and (d) JNK phosphorylation in the hearts of Ang II-infused mice was significantly increased. Etanercept treatment prevented this Ang II-induced phosphorylation. Values are mean ± SEM. *p< 0.05 vs WT+Saline, # p< 0.05 vs WT+Ang II, n = 6 per group.