A Multi-Marker Genetic Association Test Based on the Rasch Model Applied to Alzheimer’s Disease
Fig 4
Hypothetic signalling network integrating top genes identified through the Rasch analysis.
Gene abbreviations: PLXNC1—plexin C1 receptor for semaphorins; PTK2—FAK kinase implicated in integrin signalling; FYN—src family tyrosine kinase, downstream target of GRM5 receptor; EEF2K—eukaryotic elongation factor-2 kinase, activated by GRM5 receptor, regulates global protein synthesis; MDM2—negative modulator of TP53 tumour suppression gene; RPTOR—regulatory protein associated with MTORC1 complex; HDAC3—histone deacetylase; ARC—activity-regulated cytoskeleton-associated protein.