Dissecting Leishmania infantum Energy Metabolism - A Systems Perspective
Fig 3
The map of the iAS142 metabolic network—The iAS142 network comprises of 237 reactions that occur in 5 major model compartments: 4 cellular compartments—the glycosome, cytoplasm, the mitochondrion, the mitochondrial inter-membrane space and 1 extracellular compartment as shown in the Fig.
The mitochondrial inter-membrane space though included in the model, is not explicitly shown in the Fig. The reactions of oxidative phosphorylation occur from the mitochondrial compartment (m) to the mitochondrial inter-membrane space (mm) and vice versa. The reactions occurring along the borders of the compartments are transport reactions. The metabolite exchanges have been shown at the bottom of the Fig.