Pro-Oxidant Activity of Amine-Pyridine-Based Iron Complexes Efficiently Kills Cancer and Cancer Stem-Like Cells
Fig 11
Mode of action of the amine-pyridine ligands.
The cytotoxic activity of amine-pyridine ligands involves different inter-dependent processes: intracellular Fe(II) chelation, generation of ROS, DNA fragmentation through oxidative mechanisms, induction of cell cycle arrest and apoptosis.