Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor
Fig 3
ACh concentration-response for most of the functional mutants.
A. Representative current traces induced by ACh for the wild type and mutant receptors with the concentrations indicated. B. Averaged and normalized concentration-responses of charge (6–8 oocytes each group). Lines are nonlinear least squares fits of the normalized averages of the responses to the Hill equation. C. Bar graph of the pEC50 values (negative logEC50s) derived from B. ***: P<0.001 when compared to the WT value.