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Atrial SERCA2a Overexpression Has No Affect on Cardiac Alternans but Promotes Arrhythmogenic SR Ca²⁺ Triggers

Fig 1

SERCA2a overexpression in isolated atrial myocytes.

SERCA2a was overexpressed in isolated rat atrial myocytes for 24 hours. Ad.SERCA2a in isolated myocytes lead to an increase in SERCA2a expression without changing expression of other calcium cycling proteins Ryanodine Receptor (RyR), Na⁺/Ca²⁺ exchanger (NCX), and phospholamban. Westerns are depicted in A with summary data of SERCA2a overexpression (n = 4) and control myocytes (n = 4) in B.

doi: https://doi.org/10.1371/journal.pone.0137359.g001