Vasomotor Reaction to Cyclooxygenase-1-Mediated Prostacyclin Synthesis in Carotid Arteries from Two-Kidney-One-Clip Hypertensive Mice
Fig 2
Response to ACh in HTN carotid arteries with NO synthase inhibited.
A: summary of contractions evoked by 0.3 and 10 μM ACh in HTN and NTN arteries treated with 1 mM L-NAME. B: comparison of contractions evoked by 10 μM ACh in NTN and HTN vessels with those obtained in the presence of 1 μM FR122047 (+FR). C: representative traces showing the control response evoked by ACh (10 μM) in L-NAME-treated HTN arteries (top), the response obtained in the presence of 3 μM of TP receptor antagonist SQ29548 (+SQ; 2nd trace), and that in vessels denuded of the endothelium (+EC-; 3rd trace) or obtained in the presence of 3 μM TXAS inhibitor ozagrel (+OZ; bottom). D: summarized results from C. In A, B and D, values were expressed as mean ± SEM (n = 5 for each), **P<0.01; NS, not significant.