Progressive Hemorrhage and Myotoxicity Induced by Echis carinatus Venom in Murine Model: Neutralization by Inhibitor Cocktail of N,N,N',N'-Tetrakis (2-Pyridylmethyl) Ethane-1,2-Diamine and Silymarin
Fig 5
(a) Target—template sequence alignment, (b) model validation, (c) target-template structure superposition and (d) conserved active site residues. The template structures—bee venom hyaluronidase (PDB ID: 1FCQ-template 1) and human hyaluronidase (PDB ID: 2PE4- template 2) showed 33.3% and 42% sequence identity and 92% and 70% query coverage with the target sequence—Echis ocellatus venom hyaluronidase (UniProt ID: A3QVN2).