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TAT-Mediated Acidic Fibroblast Growth Factor Delivery to the Dermis Improves Wound Healing of Deep Skin Tissue in Rat

Fig 2

Evaluation of pressure-induced deep tissue injury.

A: Typical macroscopic views of the TAT-aFGF, aFGF and control groups on day 0, 3, 7, and 14. The red open ulcers remained differentially in the three groups on day 14. B: Wound contraction was measured quantitatively, showing a higher rate in the TAT-aFGF group on day 14; * p < 0.05, ** p < 0.01. C: Typical microscopic views (×100) of hematoxylin and eosin (HE) staining of each group on days 0, 3, 7 and 14. Edema and swelling were obvious on day 0. Bar = 100 μm. D: HE staining and Masson staining of tissue biopsies on day 14. Bar = 100 μm. E: Semi-quantitative scoring of sections from mice on day 14. * p < 0.05, ** p < 0.01.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0135291.g002