Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation
Fig 2
Functional analysis to visualize transcriptomic and proteomic data.
Significantly altered genes in HK-2 cells following cisplatin treatment as detected by microarray analysis (transcriptomic) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) (proteomic). Functional analysis of data was performed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). Results were visualized using the enrichment map plug-in for Cytoscape. Each circular node is a gene set with a diameter proportional to the number of genes. The inner node color represents the p-value of the enrichment analysis in the transcriptome, whereas the outer node color represents the p-value of the enrichment analysis in the proteome. The edge width is proportional to the similarity of gene sets between linked nodes. Details of the network can be examined using the scalable PDF in S1 Fig.