Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases
Fig 6
Structural comparison of DUSP3, DUSP14, DUSP22 and Cdc25B catalytic sites.
(A) Superimposed ribbon representation of structures for DUSP3 (green), DUSP14 (magenta), DUSP22 (cyan) and Cdc25B (yellow). The catalytic sites are centered on the co-crystallized phosphate or 2-(N-morpholino) ethanesulfonic acid (MES) atom. (B) Electrostatic potential surface representation of the catalytic site of DUSP3 (PDB: 1VHR), DUSP14 (PDB: 2WGP), DUSP22 (PDB: 1WRM) and Cdc25B (PDB: 1QB0). Red and blue colored regions denote negative and positive charges, respectively.