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NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure

Fig 1

Enhanced expression of hepatic B7-H6 in HBV-ACLF patients.

The detection of hepatic B7-H6 expression in patients with HBV-ACLF (Fig 1, A–G, original magnification 200x), mild CHB (Fig H, original magnification 200x), healthy controls (Fig 1I, original magnification 200x) was performed by immunohistochemical staining. B7-H6 staining with rabbit serum as first antibody was used as experimental negative controls (Fig 1J, original magnification 200x). According to the manufacturer's instructions, B7-H6 staining in human gallbladder tissue was used as the positive control (Fig 1K, original magnification 200x). Relative mean density analysis indicated that hepatic B7-H6 expression was significantly higher in HBV-ACLF patients than in mild CHB patients or in healthy controls (P < 0.05).

Fig 1

doi: https://doi.org/10.1371/journal.pone.0134568.g001