The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy
Fig 1
Identification of the inhibitory core of the myostatin prodomain.
(A) Truncation and deletion constructs of human myostatin prodomain:human Fc fusion proteins (left). Percentage inhibitory effect of each construct on myostatin activity in comparison with the full-length prodomain (f-Pro, right). (B) Recombinant myostatin-induced transcriptional activity in HEK293 human embryonic kidney cells co-transfected with a pGL3-(CAGA)12-luciferase reporter gene, pCMV-β-Gal, and various prodomain region:Fc fusion constructs. Values are the mean ± SD (n = 6). RLU, relative luminescence units.