Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration
Fig 2
Effect of deletion of ASMase on electroretinogram responses.
(A) Data analyses of scotopic ERG a-wave amplitudes from 1-, 2-, 4- and 6-month-old WT (filled circle) and KO (open circle) mice; (B) data analyses of scotopic ERG b-wave amplitudes from 1-, 2-, 4- and 6-month-old WT (filled square) and KO (open square) mice. (C) Data analyses of photopic ERG b-wave amplitudes for S cones and (D) M cones from 1-, 2-, 4- and 6-month-old WT (filled squares) and KO (open squares) mice. (E) Representative scotopic and photopic ERG signals in 6-month-old WT (black line) and KO (red line) mice. Each ERG was obtained by averaging two responses to 2.48 cd∙s/m2 flashes with an interstimulus interval of 60 seconds. Data are expressed as mean ± SE; n ≥6 (WT), ≥4 (KO) mice. *Indicates significant difference (P < 0.05) between responses in WT and ASMase KO mice.