Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases
Fig 4
Effect of myricetin on the secretion of IL-6 (Panel A), IL-8 (Panel B), and MMP-3 (Panel C) by human gingival fibroblasts stimulated with P. gingivalis (ATCC 33277) whole cells (MOI of 100) or LPS (1 μg/ml).
Gingival fibroblasts were treated for 2 h with myricetin prior to stimulation with P. gingivalis for 24 h. *, significant decrease at P < 0.05 compared to P. gingivalis-stimulated gingival fibroblasts not treated with myricetin. #, significant decrease at P < 0.05 compared to LPS-stimulated gingival fibroblasts not treated with myricetin.