AIM2 Drives Joint Inflammation in a Self-DNA Triggered Model of Chronic Polyarthritis
Fig 1
Swelling of joints in the context of Dnase2-deficiency is AIM2-dependent.
A: Aim2+/+ Dnase2-/- Ifnar1-/-, Aim2-/- Dnase2-/- Ifnar1-/-, Aim2+/+ Dnase2+/+ Ifnar1-/- and Aim2-/- Dnase2+/+ Ifnar1-/- mice were scored for joint swelling at indicated time points in a blinded fashion. Statistical significance was assessed using a two-tailed Mann-Whitney test comparing Dnase2-/- cohorts at 8, 12 or 15 months. B: Representative pictures of fore-and hind pads of Aim2+/+ Dnase2-/- Ifnar1-/-, Aim2-/- Dnase2-/- Ifnar1-/-, Aim2+/+ Dnase2+/+ Ifnar1-/- and Aim2-/- Dnase2+/+ Ifnar1-/- mice at the age of 15 month are shown.