Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling
Fig 9
Quantitative evaluation of serum and gallbladder composition of bile acids after administration of 17αE2 alone or 17αE2 plus BAR502.
(A) Gallbladder weight. (B-C) Quantitative evaluation of serum (B) and gallbladder (C) non conjugated bile acids from control animals (CTRL), animals treated with 17αE2 or animals co-administered with 17αE2 plus BAR502. (D-E) Quantitative evaluation of serum (D) and gallbladder (E) conjugated bile acids from either control animals (CTRL), animals treated with 17αE2 or animals co-administered with 17αE2 plus BAR502. Results are the mean ± SE of 4–8 animals per group. *p<0.05 versus control group (CTRL); #p<0.05 versus 17αE2 treated mice.