In Vitro-Stimulated IL-6 Monocyte Secretion and In Vivo Peripheral Blood T Lymphocyte Activation Uniquely Predicted 15-Year Survival in Patients with Head and Neck Squamous Cell Carcinoma
Fig 4
Overall survival according to low/high IL-6 monocyte secretion added to low/high CD71 T lymphocyte expression.
HNSCC/control patients (upper panel) and HNSCC patients with HPV adjustment (lower panel). Monocytes cultured as in Fig 2 and lymphocytes analyzed as in Fig 3. Patients allocated to low IL-6 and CD71 (blue continuous line), low IL-6 or CD71 (red semi-hatched line) or both high IL-6 and CD71 (orange hatched line). Cohort (upper panel): 48 HNSCC and 16 control patients. Cohort (lower panel): 42 HPV-negative and 6 HPV-positive HNSCC patients. Statistics by Kaplan-Meier analyses (Log rank test).