LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages
Fig 7
Postprandial serum lipids remain elevated in macLRP1-/- mice.
(a) Mice (macLRP1-/-, n = 11; LRP1+/+, n = 10) were fed Western diet for 3 weeks, and were then injected with Triton WR-1339 (500 mg/kg body weight), and triglyceride levels in the plasma were determined at 0, 30, 60 and 90 min following injection. The rate of triglyceride synthesis is shown. Error bars show the SEM. (b) LRP1+/+ mice (closed symbols, n = 5) or macLRP1-/- mice (open symbols, n = 5) fed a Chow diet were fasted and then received an intragastric olive oil load. Blood samples were collected at the indicated times, and plasma triglyceride levels measured. Error bars show the SEM. (Data were analyzed for statistical significance employing a two way ANOVA which confirmed significant effects for Genotype (p = 0.0012) and Time (p = 0.0001) with no significant Genotype X Time interaction).