Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle
Fig 5
A-D. Effects of TRPC3si, CD38si, STIM1si, and Orai1si on control and 1% CSE increased store-operated Ca2+ entry (SOCE) in human ASM cells. In all cell groups, depletion of sarcoplasmic reticulum Ca2+ in zero extracellular Ca2+ followed by rapid re-introduction of Ca2+ resulted in activation of SOCE. Compared to controls, 1% CSE significantly enhanced SOCE. Values are mean ± SEM. * indicates significant effect of siRNA compared to respective control (p< 0.05).