pGlcNAc Nanofiber Treatment of Cutaneous Wounds Stimulate Increased Tensile Strength and Reduced Scarring via Activation of Akt1
Fig 3
sNAG treatment causes increased tensile strength and elasticity of wounded skin.
(A) Quantitation of the relative stress wounded skin could withstand from sNAG treated and untreated WT mice. Tissue was harvested 21 days post wounded and subjected to mechanical testing. Measurements are relative to control (CTRL) skin which was derived from unwounded tissue of WT animals. n = 6 for both unwounded CTRL skin and wounded untreated and n = 5 for treated wounds. (*p<.05) (B) Quantitation of skin elasticity from sNAG treated and untreated wounds harvested 21 days post wounding from WT animals. Control skin was derived from unwounded tissue of WT animals (**p<.01). (C) Van Gieson staining of paraffin embedded tissue sections derived from unwounded skin (control), sNAG treated, and untreated wounds of WT animals 10 days post wounding. Blue arrows indicate darkly stained elastin fibers.