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HbAHP-25, an In-Silico Designed Peptide, Inhibits HIV-1 Entry by Blocking gp120 Binding to CD4 Receptor

Fig 10

HIV-1 VSV infection in the presence of HbAHP-25.

a) CEM-GFP cells were infected for 4 hrs with HIV-1 (wt) and HIV-1 VSV pre-incubated with 35.7 μM of HbAHP-25. p24 levels were checked on day 4 post infection. VRC01 (0.1μM) was used as a control. b) Intracellular p24 levels in CEM-GFP cells, infected for 1 hr with HIV-1 VSV pre-incubated with HbAHP-25 (1 hr). Values are the mean (± SD) of three different biological replicates performed on different days (**p<0.01; ***p<0.001).

Fig 10

doi: https://doi.org/10.1371/journal.pone.0124839.g010