Integrative Metabolic Signatures for Hepatic Radiation Injury
Fig 14
Role of intestinal microbiome in the response to liver Irradiation.
Normalized levels of 3-indoxyl-sulfate and 3-hydroxycinnamic acid levels from liver samples are plotted. Radiation dose-dependent increase was observed in these metabolites, indicating possible role of gut microbiome on liver injury. 3-indoxyl-sulfate and 3-hydroxycinnamic acid were both increased in the liver following exposure to radiation. These metabolites are by-products of the intestinal flora, and coupled with those in the Tryptophan pathway point to a possible gut microbiome response to radiation.