Regulation of L-type Voltage Gated Calcium Channel CACNA1S in Macrophages upon Mycobacterium tuberculosis Infection
Fig 1
Rv2463 induces the upregulation of CACNA1S on macrophages.
J774 macrophages were stimulated with Rv2463 at indicated concentrations and for indicated times. CACNA1S expression on cell surface was monitored by flow cytometry. Bold lines represent stimulations with Rv2463 while dotted lines represent unstimulated controls. Data from one of four independent experiments are shown. P<0.020; for unstimulated v/s 5 μg/ml of Rv2463; P<0.015, for unstimulated v/s 10 μg/ml of Rv2463; P<0.005, for unstimulated v/s 25 μg/ml of Rv2463. P values were calculated for 48h time point. Two-tailed Student’s t-test was employed for P values.