Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling
Fig 6
The 14-3-3ζ, Cby, β-catenin tripartite complex.
Model of dimeric 14-3-3ζ bound to two molecules of full-length Cby. The models of two full-length Cby proteins have disordered residues 30–73 of the N-terminus and 100–126 of the C-terminus presented in a highly extended fashion, and are shown forming a coiled-coil from residues 73–100. β-catenin (PDB: 2Z6H) is shown with its Cby binding-site (helix C) in red which then binds along the C-terminus (64–126) of Cby.