A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research
Fig 8
Progressive enlargement of the lymphatic vessel diameter during the early phases of skin inflammation.
A Prox1-Cre-tdTomato mice (n = 5) were imaged at 0, 6, 20 and 48 hrs after the induction of a cutaneous hypersensitivity reaction by intravital confocal microscopy. Scale bars: 100 μm. B Morphological analysis revealed progressive enlargement of the LV diameter over time. Data represent means ± SEM, statistical significance was analyzed using the unpaired student t-test, *p<0.05. C Ear thickness increased over time. Data represent means ± SEM, statistical significance was analyzed using 1-way ANOVA and Dunnett’s post test, ***p<0.0001.