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Maternal Obesity in Sheep Increases Fatty Acid Synthesis, Upregulates Nutrient Transporters, and Increases Adiposity in Adult Male Offspring after a Feeding Challenge

Fig 3

Plasma glucose (a) and insulin (b) responses to a glucose tolerance test in male offspring of control ewes (○, n = 7) fed 100% of NRC recommendations and obese ewes (●, n = 6) fed 150% of NRC recommendations.

Area under the curve (AUC) is shown in insert. Values are means ± SEM. a) Trt P < 0.0001, time P < 0.0001, Trt x time P < 0.0001; and b) Trt P = 0.0002, time P < 0.0001, Trt x time P < 0.0001. * Mean differences (P < 0.05) and ** mean differences (P < 0.01) at a specific time point between control and obese offspring.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0122152.g003