Migration of Myeloid Cells during Inflammation Is Differentially Regulated by the Cell Surface Receptors Slamf1 and Slamf8
Fig 1
Slamf8 negatively and Slamf1 positively affects DC migration from the skin to draining lymph nodes after Hapten-FITC sensitization.
(A) Representative dot plots (gated on CD11c+ cells) and (B) percentages of migratory MHC-IIhi FITC+ DCs in the draining LNs of wt and Slamf8-/- mice, 24 h after painting dorsal skin with Hapten-FITC. Total number of migratory (CD11c+MHC-IIhiFITC+) DCs in the draining Lymph Nodes (LNs) of (C) Slamf8-/- mice or (D) Slamf1-/- mice, 24 h after FITC painting. Values represent mean. The data are representative of three or more independent experiments.