IMD-4690, a Novel Specific Inhibitor for Plasminogen Activator Inhibitor-1, Reduces Allergic Airway Remodeling in a Mouse Model of Chronic Asthma via Regulating Angiogenesis and Remodeling-Related Mediators
Fig 4
Anti-allergic effects of IMD-4690 in the chronic asthma model of mice.
(A) Histopathology (Giemasa stain) in the lungs. Arrowheads indicate eosinophils. Original magnification in all figures: ×400. Scale bars in all figures = 100 μm. The number of eosinophils in the subepithelium is also counted and expressed as a graph. (B) PAS staining in the lungs. The PAS-positive cells indicate mucous metaplasia. The number of PAS-positive cells is counted and expressed as a graph. (C-H) Cytokine levels in mouse lung homogenates (C-H) and serum (C, D). IL-5 (C), IL-13 (D), IL-4 (D), TNF-α (E), IL-12 (F) and IFN-γ were measured by ELISA. Data are expressed as means ± SE of six mice. *P < 0.05 compared with control/CMC mice, †P < 0.05 compared with Dp/CMC mice.