HP1β Is a Biomarker for Breast Cancer Prognosis and PARP Inhibitor Therapy
Fig 5
HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy.
Respective HP1 expression level is frequently altered in breast cancer cells, suggesting the diverse role of each HP1 subtype in breast cancers. This model shows that the expression level of HP1 subtype in breast cancer cells may be either decreased or increased according to cancer stage, grade, cancer cell proliferation (Ki-67) and aggressiveness. PARP inhibitor therapy may be an effective therapy for patients with no/low HP1β expression. Combination therapy with epigenetic drugs (including H3K9 methylation inhibitors) or alternative therapy is necessary for patients with breast cancers of high HP1 abundance.