α1B-Adrenergic Receptors Differentially Associate with Rab Proteins during Homologous and Heterologous Desensitization
Fig 10
Time-course of the α1B-adrenergic receptor-Rab 5 interaction.
Panel A: FRET index images of cells coexpressing Ds-Red-tagged α1B-adrenergic receptors and EGFP-tagged Rab 5 treated for the times indicated with 10 μM noradrenaline (NA) or sphingosine 1-phosphate (S1P). Scale bars: 15 μm. Panel B: Quantitative analysis of the data presented in Panel A. Plotted are the means and vertical lines representing the S.E.M of 5–7 experiments using different cell preparations. Noradrenaline, blue line and symbols; sphingosine 1-phosphate, brown line and symbols.