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Analyses of the Transcriptome and Metabolome Demonstrate That HIF1α Mediates Altered Tumor Metabolism in Clear Cell Renal Cell Carcinoma

Fig 3

Metabolomic analysis of key intermediates in glycolysis, lactate production, and the TCA cycle in ccRCC samples.

A: Comparison of the levels of glycolysis and lactate production intermediates, glucose, pyruvate, and lactate in normal vs. ccRCC samples (n = 12). = Normal; ■ = ccRCC. B: Comparison of the levels of fumarate, α-ketoglutarate, and citrate/isocitrate in normal vs. ccRCC samples (n = 12). = Normal; ■ = ccRCC. C: Schematic overview of changes to glycolysis, lactate production, and the TCA cycle in ccRCC. Error bars indicate the mean ± SD. * indicates a p value <0.05, ** indicates a p value <0.01, and *** indicates a p value <0.001.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0120649.g003