Proteomic Analysis of INS-1 Rat Insulinoma Cells: ER Stress Effects and the Protective Role of Exenatide, a GLP-1 Receptor Agonist
Fig 3
Differential protein expression during INS-1 cell death induced by ER stress and its prevention by exenatide on 2D-PAGE separation.
After 6 h treatment of thapsigargin alone or thapsigargin plus exenatide, lysates of INS-1 cells were separated on 2D-PAGE and visualized by silver staining. Arrow denotes the differentially expressed protein spots shown in thapsigargin alone compared to untreated control. Direction of change was denoted as alphabet “D” (down) or “U” (up) in front of each spot number.