Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3β (GSK-3β) and Microtubule-Associated Protein 1B
Fig 7
A model for repulsive draxin signaling.
Draxin interaction with DCC triggers inactivation of the Akt pathway. This relieves GSK-3β from Akt-mediated inhibition leading to an increase in phosphorylation of MAP1B and reconfiguration of the cytoskeleton to promote growth cone collapse and inhibition of neurite extension.