Untargeted Metabolomic Analysis of Human Plasma Indicates Differentially Affected Polyamine and L-Arginine Metabolism in Mild Cognitive Impairment Subjects Converting to Alzheimer’s Disease
Fig 2
Multivariate models comparing groups and s-plots indicating the ‘ions of interest’.
Groups were compared in pairs with Controls (red circles), MCI (black squares) and MCI_AD (blue triangles) indicated on OPLS-DA scores plots (Fig. 2A, 2C and 2E). (a) Ctrl vs. MCI; R2 = 97.6%; Q2 = 95.3%; (c) Ctrl vs. MCI_AD; R2 = 98.4%; Q2 = 95.7%. (f) MCI vs. MCI_AD; R2 = 98.7%; Q2 = 95.8%. Corresponding s-plots (Fig. 2B, 2D and F) highlight which ions are up or down regulated in their respective group as represented by the colour and shape of the variables.