OVCAR-3 Spheroid-Derived Cells Display Distinct Metabolic Profiles
Fig 2
Hierarchical clustering demonstrates clear separation between cell type and major trends in analyte levels.
Columns represent hierarchically clustered samples, color-coded according to cell type. Rows represent hierarchically clustered analytes, with the metabolites mentioned in the main text specifically labeled (metabolites from the arginine and proline metabolism pathway are annotated with an *). Metabolite levels are mean-centered and unit-variance on a per-metabolite basis. The intracellular profile consists of two major groups with clearly separate behavior between the cell types. In group 1, OCC analyte levels are generally higher than OCSC analyte levels. Group 2 analyte levels are lower in OCCs than OCSCs.