Molecular Characterization of the Peripheral Airway Field of Cancerization in Lung Adenocarcinoma
Fig 4
IPA was used to generate a network of molecules from mRNA and miRNA that were significantly different in peripheral airway field of cancerization in lung cancer patients compared to smoker controls. This composite network merge three top networks based on “network score,” which converges on the ERK/MAPk pathway: specifically merging on Extracellular signal-related kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases (JNKs), and p38 kinases subfamily. Red is up-regulated and Green is down-regulated.