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Alterations of BDNF and trkB mRNA Expression in the 6-Hydroxydopamine-Induced Model of Preclinical Stages of Parkinson’s Disease: An Influence of Chronic Pramipexole in Rats

Fig 2

The influence of 6-OHDA, pramipexole and imipramine on BDNF mRNA in the hippocampus.

The results are expressed as the mean ± S.E.M. LESION—lesioned rats, IMI—imipramine, PRA—pramipexole, Q-B/pixel2—the mean optical density-background per area units, SAL—saline, SHAM—sham-operated rats, n = 7–10, differences between SHAM-SAL vs. other groups are indicated by *p≤0.05, and differences between LESION-SAL vs. other groups by #p≤0.05). For further explanations see Fig. 1.

Fig 2

doi: https://doi.org/10.1371/journal.pone.0117698.g002