Combinations of β-Lactam or Aminoglycoside Antibiotics with Plectasin Are Synergistic against Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus
Fig 1
Time-kill analysis showing the effects of plectation in combination with amoxicillin, gentamicin and neomycin against log phase MSSA and MRSA.
The peptide and antibiotics alone or each combined with plectasin were added to the log-phase cultures and CFU counts were carried out at different time points. Combination of plectasin (2 mg/L) and amoxicillin (1 mg/L or 512 mg/L) against MSSA (A) and MRSA (B). Combination of plectasin (2 mg/L) and gentamicin (0.25 and 0.5 mg/L) against MRSA (C) and MRSA (D). Combination of plectasin (2 mg/L) and neomycin (0.25 and 0.5 mg/L) against MSSA (E) and MRSA (F). Results shown are the mean of three independent experiments.