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Serum Proteomic Changes after Randomized Prolonged Erythropoietin Treatment and/or Endurance Training: Detection of Novel Biomarkers

Fig 4

Spots with an overall Darbepoietin-α effect.

For the spots G and F that exhibited a significant Darbepoietin-α effect are shown average change in spot intensity. SP (sedentary-placebo), SE (sedentary-ESA), TP (training-placebo), and TE (training-ESA). The dark grey box at the bottom indicates the boosting period (first 3 weeks) and the light grey box the maintenance period (weeks 4–10), subjects were not treated during weeks 11–13 (wash-out phase). Individual changes (%) from baseline in all subjects in the TE and SE group are also shown. Data are expressed as mean ± SE, level of significance are p<0.05. * significant from SP within same time-point, # significant from different time-point within group (time point are given), § significant from TP within same time-point, ¤ significant from SE within same time-point.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0117119.g004