MiR-1178 Promotes the Proliferation, G1/S Transition, Migration and Invasion of Pancreatic Cancer Cells by Targeting CHIP
Fig 3
MiR-1178 accelerates pancreatic cancer cell migration and invasion.
Cell migration and invasion were analyzed in membrane-containing transwells without or with Matrigel. Cells that had migrated or invaded to the lower surface of the membrane were stained with hematoxylin and eosin and counted under a microscope at 100× magnification. (A) The up-regulation of miR-1178 by transfection of the mimics enhanced cell invasion, while miR-1178 down-regulation deterred cell invasion. (B) Over-expression of miR-1178 promoted cell migration, while the down-regulation of miR-1178 inhibited cell migration. * P＜ 0.05, ** P < 0.01.