Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
Figure 4
Progression to severe HIV-related CNS injury.
The figure outlines a simple diagram of transition from asymptomatic NFL- infection to either ‘quiet’ NFL+ injury or HAD. It emphasizes that both have CD4+ T-cell loss in common but then diverge for undefined reasons, possibly related to viral evolution of host inflammatory/immune activation characteristics. Further study is needed to understand the factors operating in this transition. It also has not been defined whether either of these two injury states can transition to the other.