Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
Figure 2
Ratios of selected neuronal biomarkers.
The plots are similar in format to those of Fig. 1, but plot ratios (log10 differences) of selected neuronal biomarkers on log10 scales that differ in relation to the magnitude and ranges of the differences. A. Ratio of CSF p-tau to t-tau in the nine groups. Only the HAD group differed from any of the others in Dunn's multiple comparison test: compared to Rx suppressed and CD4 >350 (p<0.0001); to CD4 200–349 (p<0.01); and to CD4 50–199 (p<0.05). B. Ratio of CSF NFL to CSF sAPPβ. HAD group differed from HIV- and PHI (p<0.0001), from Rx suppressed, CD4+>350, CD4+200–349, CD4+50–199 (p<0.001); CD4<50 differed from HIV- (p<0.001) and from CD4+>350 (p<0.05). C. Ratio of CSF t-tau to sAPPβ. The HAD group differed from HIV-, Rx suppressed and PHI (p<0.0001), from CD4 200–349 (p<0.001), from CD4 >350 (p<0.01), from CD4 50–199 and from PHI (p<0.05); CD4<50 differed from PHI (p<0.05).