Systems Biology Investigation of cAMP Modulation to Increase SMN Levels for the Treatment of Spinal Muscular Atrophy
Figure 4
Development of the simplified cAMP:SMN2 model.
Simplified cAMP model captures essential functions of cAMP signaling. (A) The original cAMP model generated by Williamson et al. [33]. (B) Simplified cAMP model. (C) Predicted concentrations of activated G proteins (GPa; blue lines), activated PKA (PKAa; green lines) and cAMP (red lines) following addition of glucose. The solid lines represent the predictions based on the simplified cAMP model while the dashed lines represent data points obtained from [34], [35].