Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice
Figure 2
Physiochemical properties of the bile salt pool.
Bile was canulated for 20 minutes and feces was collected 72 hr prior to termination of chow-fed PBS-injected and the liver-specific scAAV-FXRα2 or scAAV-FXRα4 transduced FXR knock-out mice. Total biliary (A) and fecal (C) bile salt composition are similar between 3 groups. The biliary (B) and fecal (D) bile salt origins show differences between the 3 groups. (α-MCA; α-muricholate, β-MCA; β-muricholate, ω-MCA; ω-muricholate, CDCA; chenodeoxycholate, HDCA; hyodeoxycholate, DCA; deoxycholate, CA; cholate. We consider cholate and deoxycholate as CA-derived bile salts and the others as CDCA-derived bile salts. Values are presented as average ± standard deviations (n = 6 animals per group). *p<0.05 vs. PBS; #P<0.05 between FXR isoforms.