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Metabolic Profiling of Alternative NAD Biosynthetic Routes in Mouse Tissues

Figure 5

Correlation between the physiological levels of products (NAD or NaAD) and substrates (NMN or NaMN) of the NMNAT-catalyzed reaction in different mouse tissues.

Average values ± standard errors are those depicted in Figure 4. The “AMIDATED” refers to grouped NAD and NMN levels in the indicated tissues; the group “DEAMIDATED” refers to levels of NaAD and NaMN (smaller circle) in the same tissues (not detailed). The linear relationship in different tissues between the steady-state levels of NAD and NaAD relative to NMN and NaMN, respectively, is highlighted. The “outlier” square symbol (▪) represents blood, where diverging values were observed compared to all other examined tissues.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0113939.g005